abstract：:Cell-based therapy is a promising approach for many diseases, including ischemic heart disease. Cardiac mesoangioblasts are committed vessel-associated progenitors that can restore to a significant, although partial, extent, heart structure and function in a murine model of myocardial infarction. Low-intensity pulsed ...

journal_title：Stem cell reviews and reports

authors： Bernal A,Pérez LM,De Lucas B,Martín NS,Kadow-Romacker A,Plaza G,Raum K,Gálvez BG

更新日期：2015-12-01 00:00:00

abstract：:Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particular protocol to robustly obtain cardiomyocytes from multiple...

journal_title：Stem cell reviews and reports

authors： Kadari A,Mekala S,Wagner N,Malan D,Köth J,Doll K,Stappert L,Eckert D,Peitz M,Matthes J,Sasse P,Herzig S,Brüstle O,Ergün S,Edenhofer F

更新日期：2015-08-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) is a highly specialized cell type located between the choroid and neural retina of the eye. RPE degeneration causes irreversible visual impairment, extending to blindness. Cell therapy has recently emerged as a potential therapeutic approach for retinal degeneration. MicroRNA-based...

journal_title：Stem cell reviews and reports

authors： Choi SW,Kim JJ,Seo MS,Park SB,Kang TW,Lee JY,Lee BC,Kang I,Shin TH,Kim HS,Yu KR,Kang KS

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from the chorionic villi of human term placenta (pMSCs) have drawn considerable interest because of their multipotent differentiation potential and their immunomodulatory capacity. These properties are the foundation for their clinical application in the fields of stem cell tra...

journal_title：Stem cell reviews and reports

authors： Abomaray FM,Al Jumah MA,Kalionis B,AlAskar AS,Al Harthy S,Jawdat D,Al Khaldi A,Alkushi A,Knawy BA,Abumaree MH

更新日期：2015-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are adult, self-renewable, multipotent cells that can be found in almost all postnatal tissues. Because of their capacity for self-renewal and differentiation into tissues of mesodermal origin and due to their immunomodulatory ability, MSCs are used in many preclinical and clinical studie...

journal_title：Stem cell reviews and reports

authors： Gazdic M,Volarevic V,Arsenijevic N,Stojkovic M

更新日期：2015-04-01 00:00:00

abstract：:The interest in the use of stem cells as a source for therapy has increased dramatically over the last decades. Different stem cell types have been tested in both in vitro and in vivo models, because of their properties such as differentiation potential, trophic effects and immune modulatory properties. To further opt...

journal_title：Stem cell reviews and reports

authors： Wolfs E,Verfaillie CM,Van Laere K,Deroose CM

更新日期：2015-04-01 00:00:00

abstract：:Factors responsible for the rapid proliferative properties of embryonic stem (ES) cells are largely unknown. MicroRNA-221/222 (miR-221/222) regulate proliferation in many somatic cells, however, their roles in proliferation of ES cells are unclear. In this study, E14 mouse ES cells proliferation was determined by tota...

journal_title：Stem cell reviews and reports

authors： Li J,Bei Y,Liu Q,Lv D,Xu T,He Y,Chen P,Xiao J

更新日期：2015-02-01 00:00:00

abstract：:Recent advances on human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have brought us closer to the realization of their clinical potential. Nonetheless, tissue engineering and regenerative medicine applications will require the generation of ...

journal_title：Stem cell reviews and reports

authors： Fan Y,Wu J,Ashok P,Hsiung M,Tzanakakis ES

更新日期：2015-02-01 00:00:00

abstract：:Islet transplantation has been hampered by the shortage of islet donors available for diabetes therapy. However, pluripotent stem cells (PSCs) can be an alternative source of insulin-producing cells (IPCs) because of their capacity for self-renewal and differentiation. We described a method to efficiently differentiat...

journal_title：Stem cell reviews and reports

authors： Oh BJ,Oh SH,Choi JM,Jin SM,Shim WY,Lee MS,Lee MK,Kim KW,Kim JH

更新日期：2015-02-01 00:00:00

abstract：:The propensity of induced pluripotent stem (iPS) cells to differentiate into specific lineages may be influenced by a number of factors, including the selection of the somatic cell type used for reprogramming. Herein we report the generation of new iPS cells, which we derived from human articular chondrocytes and from...

journal_title：Stem cell reviews and reports

authors： Guzzo RM,Scanlon V,Sanjay A,Xu RH,Drissi H

更新日期：2014-12-01 00:00:00

abstract：:The practice of travelling abroad to receive unproven and unregulated stem cell treatments has become an increasingly problematic global phenomenon known as 'stem cell tourism'. In this paper, we examine representations of nine major clinics and providers of such treatments on the microblogging network Twitter. We col...

journal_title：Stem cell reviews and reports

authors： Kamenova K,Reshef A,Caulfield T

更新日期：2014-12-01 00:00:00

abstract：:Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferat...

journal_title：Stem cell reviews and reports

authors： Wan X,Liu L,Ding X,Zhou P,Yuan X,Zhou Z,Hu P,Zhou H,Li Q,Zhang S,Xiong S,Zhang Y

更新日期：2014-10-01 00:00:00

abstract：:Converting adult cells from one cell type to another is a particularly interesting idea for regenerative medicine. Terminally differentiated cells can be induced to de-differentiate in vitro to become multipotent progenitors. In mammals these changes do not occur naturally, however exposing differentiated adult cells ...

journal_title：Stem cell reviews and reports

authors： Brevini TA,Pennarossa G,Rahman MM,Paffoni A,Antonini S,Ragni G,deEguileor M,Tettamanti G,Gandolfi F

更新日期：2014-10-01 00:00:00

abstract：:The stem-cell-based tissue-engineering approaches are widely applied in establishing functional organs and tissues for regenerative medicine. Successful generation of induced pluripotent stem cells (iPS cells) and rapid progress of related technical platform provide great promise in the development of regenerative med...

journal_title：Stem cell reviews and reports

authors： Liu P,Zhang Y,Chen S,Cai J,Pei D

更新日期：2014-10-01 00:00:00

abstract：:The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchym...

journal_title：Stem cell reviews and reports

authors： Naaijkens BA,van Dijk A,Kamp O,Krijnen PA,Niessen HW,Juffermans LJ

更新日期：2014-06-01 00:00:00

abstract：:We previously showed the emergence of predominantly non-fused murine cells co-expressing cardiac and stromal determinants in co-cultures of murine mesenchymal stromal cells (MSCs) and rat embryonic cardiomyocytes. To determine whether a similar phenotype is detectable in vivo in ischemic myocardium, we infused green f...

journal_title：Stem cell reviews and reports

authors： Yannarelli G,Tsoporis JN,Desjardins JF,Wang XH,Pourdjabbar A,Viswanathan S,Parker TG,Keating A

更新日期：2014-04-01 00:00:00

abstract：:The challenges in limbal stem cell biology largely remain in the process of identification, isolation and expansion of these adult corneal epithelial stem cells of the eye. Due to the absence of specific limbal stem cell markers, identification and isolation of putative limbal stem cells is a complicated task. The sid...

journal_title：Stem cell reviews and reports

authors： Shaharuddin B,Harvey I,Ahmad S,Ali S,Meeson A

更新日期：2014-04-01 00:00:00

abstract：:Brain injury continues to be one of the leading causes of disability worldwide. Despite decades of research, there is currently no pharmacologically effective treatment for preventing neuronal loss and repairing the brain. As a result, novel therapeutic approaches, such as cell-based therapies, are being actively purs...

journal_title：Stem cell reviews and reports

authors： Jezierski A,Rennie K,Zurakowski B,Ribecco-Lutkiewicz M,Haukenfrers J,Ajji A,Gruslin A,Sikorska M,Bani-Yaghoub M

更新日期：2014-04-01 00:00:00

abstract：:Human pluripotent stem cells (PSCs) are critical in vitro tools for understanding mechanisms that regulate lineage differentiation in the human embryo as well as a potentially unlimited supply of stem cells for regenerative medicine. Pluripotent human and mouse embryonic stem cells (ESCs) derived from the inner cell m...

journal_title：Stem cell reviews and reports

authors： Gkountela S,Li Z,Chin CJ,Lee SA,Clark AT

更新日期：2014-04-01 00:00:00

abstract：:The development of pluripotent cells that enable stem cell research (SCR) without destroying human embryos is now a leading priority for science. Public and political controversies associated with human embryonic SCR experienced in the recent past should be alleviated if scientists no longer need to harvest cells from...

journal_title：Stem cell reviews and reports

authors： Critchley CR,Bruce G,Farrugia M

更新日期：2013-10-01 00:00:00

abstract：:Here we present the principles and steps of a protocol that we have recently developed for the differentiation of hES/iPS cells into the authentic human striatal projection medium spiny neurons (MSNs) that die in Huntington's Disease (HD). Authenticity is judged by the convergence of multiple features within individua...

journal_title：Stem cell reviews and reports

authors： Delli Carri A,Onorati M,Castiglioni V,Faedo A,Camnasio S,Toselli M,Biella G,Cattaneo E

更新日期：2013-08-01 00:00:00

abstract：:The reprogramming of adult somatic cells into an embryonic stem cell (ESC) state by various means has opened a new chapter in basic and applied life science. While this technology will create great opportunities for regenerative medicine, the more immediate impact is likely to be found in human disease modeling and dr...

journal_title：Stem cell reviews and reports

authors： Morshedi A,Soroush Noghabi M,Dröge P

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Whether transplanted cardiac stem cells (CSCs) and mesenchymal stem cells (MSCs) improved ventricular fibrillation threshold (VFT) similarly is still unclear. We sought to compare the effects of the CSC and MSC transplantation on the electrophysiological characteristics and VFT in rats with myocardial infa...

journal_title：Stem cell reviews and reports

authors： Zheng SX,Weng YL,Zhou CQ,Wen ZZ,Huang H,Wu W,Wang JF,Wang T

更新日期：2013-06-01 00:00:00

abstract：:Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which...

journal_title：Stem cell reviews and reports

authors： Gajzer DC,Balbin J,Chaudhry HW

更新日期：2013-06-01 00:00:00

abstract：:The facile regeneration of undifferentiated human mesenchymal stem cells (hMSCs) from thermoresponsive surfaces facilitates the collection of stem cells avoiding the use of animal derived cell detachment agents commonly used in cell culture. This communication proposes a procedure to fabricate coatings from commercial...

journal_title：Stem cell reviews and reports

authors： Nash ME,Fan X,Carroll WM,Gorelov AV,Barry FP,Shaw G,Rochev YA

更新日期：2013-04-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) from umbilical cord blood have been successfully used to treat blood disorders but one major hurdle is the relatively low cell dose available. Double cord blood unit transplantation results in elevated engraftment failure because one unit predominates over the other. Various approaches ...

journal_title：Stem cell reviews and reports

authors： Lin HD,Bongso A,Gauthaman K,Biswas A,Choolani M,Fong CY

更新日期：2013-04-01 00:00:00

abstract：:Undifferentiated mouse embryonic stem cells (ESCs) possess low numbers of mitochondrial DNA (mtDNA), which encodes key subunits associated with the generation of ATP through oxidative phosphorylation (OXPHOS). As ESCs differentiate, mtDNA copy number is regulated by the nuclear-encoded mtDNA replication factors, which...

journal_title：Stem cell reviews and reports

authors： Kelly RD,Sumer H,McKenzie M,Facucho-Oliveira J,Trounce IA,Verma PJ,St John JC

更新日期：2013-02-01 00:00:00

abstract：:The combination of cell therapy with growth factors could be a useful approach to treat progressive muscular dystrophies. Here, we demonstrate, for the first time, that IGF-1 considerably enhances the myogenesis of human umbilical cord (UC) mesenchymal stromal cells (MSCs) in vitro and that IGF-1 enhances interaction ...

journal_title：Stem cell reviews and reports

authors： Secco M,Bueno C Jr,Vieira NM,Almeida C,Pelatti M,Zucconi E,Bartolini P,Vainzof M,Miyabara EH,Okamoto OK,Zatz M

更新日期：2013-02-01 00:00:00

abstract：:Chronic articular cartilage defects are the most common disabling conditions of humans in the western world. The incidence for cartilage defects is increasing with age and the most prominent risk factors are overweight and sports associated overloading. Damage of articular cartilage frequently leads to osteoarthritis ...

journal_title：Stem cell reviews and reports

authors： Preitschopf A,Zwickl H,Li K,Lubec G,Joo G,Rosner M,Hengstschläger M,Mikula M

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Evaluation of potential tropic effects of vascular endothelial growth factor (VEGF) on the incorporation and differentiation of bone-marrow-derived stem cells (BMSCs) in a murine model of anterior ischemic optic neuropathy (AION). METHODS:In the first approach, small-sized subset of BMCs were isolated from GFP...

journal_title：Stem cell reviews and reports

authors： Avraham-Lubin BC,Goldenberg-Cohen N,Sadikov T,Askenasy N

更新日期：2012-12-01 00:00:00

abstract：:During the process of development, neural crest cells migrate out from their niche between the newly formed ectoderm and the neural tube. Thereafter, they give rise not only to ectodermal cell types, but also to mesodermal cell types. Cell types with neural crest ancestry consequently comprise a number of specialized ...

journal_title：Stem cell reviews and reports

authors： Kaltschmidt B,Kaltschmidt C,Widera D

更新日期：2012-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are promising tools for studying the mechanisms of development and for the regeneration of injured tissues. Correct selection of the MSCs source is crucial in order to obtain a more efficient treatment and, in this respect Periosteum-Derived Cells (PDPCs) may represent an interesting alte...

journal_title：Stem cell reviews and reports

authors： Ferretti C,Borsari V,Falconi M,Gigante A,Lazzarini R,Fini M,Di Primio R,Mattioli-Belmonte M

更新日期：2012-09-01 00:00:00

abstract：:Understanding the genetic and molecular mechanisms of ovarian cancer has been the focus of research efforts working toward the greater goal of improving cancer therapy for patients with residual disease after initial treatment with conventional surgery and neoadjuvant chemotherapy. The focus of this review will be cen...

journal_title：Stem cell reviews and reports

authors： Aguilar-Gallardo C,Rutledge EC,Martínez-Arroyo AM,Hidalgo JJ,Domingo S,Simón C

更新日期：2012-09-01 00:00:00

abstract：:Zinc-finger nucleases (ZFNs) are sequence-specific genome engineering tools with great potential for the development of gene therapies. The achievement of permanent cures through gene therapy requires targeting of stem cells but the effects and/or side effects of ZFN treatment on adult stem cell potency are largely un...

journal_title：Stem cell reviews and reports

authors： Höher T,Wallace L,Khan K,Cathomen T,Reichelt J

更新日期：2012-06-01 00:00:00

abstract：:The vertebrate early stage embryo is consisting of the three primary germ layers ectoderm, mesoderm and endoderm, from which all organ tissues are developed. During early embryonic development, mesodermal cells become sequentially determined to more precisely defined cell types including muscle, heart, vasculature, bl...

journal_title：Stem cell reviews and reports

authors： Doss MX,Gaspar JA,Winkler J,Hescheler J,Schulz H,Sachinidis A

更新日期：2012-03-01 00:00:00

abstract：:Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression prof...

journal_title：Stem cell reviews and reports

authors： Lachtermacher S,Esporcatte BL,Fortes Fda S,Rocha NN,Montalvão F,Costa PC,Belem L,Rabischoffisky A,Faria Neto HC,Vasconcellos R,Iacobas DA,Iacobas S,Spray DC,Thomas NM,Goldenberg RC,de Carvalho AC

更新日期：2012-03-01 00:00:00

abstract：:Pre-clinical studies have supported the use of mesenchymal stem cells (MSC) to treat highly prevalent neurodegenerative diseases such as Parkinson's disease (PD) but preliminary trials have reported controversial results. In a rat model of PD induced by MPTP neurotoxin, we first observed a significant bilateral preser...

journal_title：Stem cell reviews and reports

authors： Pereira MC,Secco M,Suzuki DE,Janjoppi L,Rodini CO,Torres LB,Araújo BH,Cavalheiro EA,Zatz M,Okamoto OK

更新日期：2011-11-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) can be propagated indefinitely in vitro in an undifferentiated pluripotent state, can differentiate into derivatives of all three germ layers and are of considerable interest for applications in regenerative medicine. Clinical application of hESCs, however, requires reliable protocol...

journal_title：Stem cell reviews and reports

authors： Wagh V,Meganathan K,Jagtap S,Gaspar JA,Winkler J,Spitkovsky D,Hescheler J,Sachinidis A

更新日期：2011-09-01 00:00:00

abstract：:In this report we review the concept of standardization and propose an exhaustive framework for the proper management of technology on pluripotent stem cells based on studies of global and regional initiatives. We demonstrated detailed observational analysis on global initiatives for the standardization of related tec...

journal_title：Stem cell reviews and reports

authors： Sengoku S,Sumikura K,Oki T,Nakatsuji N

更新日期：2011-06-01 00:00:00

abstract：:Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy...

journal_title：Stem cell reviews and reports

authors： Huang Y,Enzmann V,Ildstad ST

更新日期：2011-06-01 00:00:00